Endocrine Abstracts

Mildronate, a γ-butyrobetaine analogue is actually used as an antiischemic drug. It was also shown to have effect on mechanisms of glucose utilization.Methods: Diabetes mellitus in Wistar rats was induced by injection of streptozotocin (50 mg/kg). Experimental rats were treatment with Mildronate (100 mg/kg daily, per os) for 6 weeks. Weight, blood glucose concentration, blood triglyceride concentration, blood ketone body concentration, glycat...

Background and aim: The role of derangements of nitric oxide (NO) metabolism in the pathogenesis of complications of type 1 diabetes mellitus (T1D) is not sufficiently clear. There is little data on simultaneous measurements of NO metabolites nitrite and nitrate (NO2/NO3) in urine and serum in T1D. Data about the measurement of NO production by electronparamagnetic spectroscopy (EPR) in whole blood in T1D were never published. To fill this gap we have cha...

Introduction: Diabetic nephropathy is a major complication of diabetes mellitus. Involvement of abnormal nitric oxide (NO) production, both via nitric oxide synthase (NOS) dependent and independent pathways (for example, xantine oxoridoreductase (XOR)) has been discussed. New compounds to treat diabetic nephropathy are searched intensively, some novel dihydropirine class drugs (DHP) have been proposed for this purpose.Aim: To study the changes in NO conc...

Introduction: A possible involvement of proteasomes in the pathogenesis of type II diabetes mellitus has been recently reported. Therefore, association of polymorphism of proteosomal genes with type II diabetes mellitus is of particular interest. In this study, molecular markers of the proteasomal alpha subunit 6 gene PSMA6 and its adjacent genomic sites have been analyzed.The goal of this study was to characterize polymorphisms of the HSMS801, HSMS702, ...

Background: Hypoxia, oxidative stress and inflammation induced by hyperglycaemia are ‘key players’ in development of diabetic complications.Aim: To analyze differences in levels of nitric oxide (NO) and its metabolites nitrate and nitrite (NO2/NO3) and well as angiopoietin 2 (Ang2) and neuropeptide Y (NPY) in patients with type 1 diabetes and different complications status; to analyze associations between these markers.Me...

Introduction: Metformin improves hyperglycaemia via mechanisms which include activation of AMP-activated protein kinase (AMPK). Recent findings indicate that some metabolic actions of metformin occur also by AMPK-independent mechanisms.Objective: To study the action of metformin on expression of GLUT1 glucose transporter in rat models of severe and mild stretozotocin diabetes mellitus.Materials and methods: Severe diabetes mellitus...